USP19 and LAMTOR4

Data Source:
BioGRID (two hybrid)

		USP19	LAMTOR4
Description		ubiquitin specific peptidase 19	late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane	Lysosome Lysosomal Membrane Intracellular Membrane-bounded Organelle Ragulator Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Hsp90 Protein Binding Lys48-specific Deubiquitinase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Regulation Of Protein Stability Response To Endoplasmic Reticulum Stress Negative Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Protein K48-linked Deubiquitination Positive Regulation Of Cell Cycle Process Regulation Of Cellular Response To Hypoxia Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of ERAD Pathway	Cell Cycle Arrest Regulation Of Cell Size Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Regulation Of Catalytic Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus
Pathways		Ub-specific processing proteases	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: BIRC3 CKAP5 ECEL1 FLNA HIF1A HNRNPAB HSP90AA1 LAMTOR4 RNF2 SIAH1 SIAH2 SNRNP200 UBC	2 interacting genes: LAMTOR5 USP19
Entrez ID		10869	389541
HPRD ID		18278	17380
Ensembl ID		ENSG00000172046	ENSG00000188186
Uniprot IDs		O94966	A0A087WT92 A0A087WV46 Q0VGL1
PDB IDs		1WH0 4X3G 6K7W 6KHV 6KQV	5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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