ACAP1 and UQCRB

Data Source:
BioGRID (two hybrid)

		ACAP1	UQCRB
Description		ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	ubiquinol-cytochrome c reductase binding protein
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GO Annotations	Cellular Component	Membrane Recycling Endosome Membrane	Mitochondrial Inner Membrane Mitochondrial Respirasome Mitochondrial Respiratory Chain Complex III
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Transport Positive Regulation Of GTPase Activity	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration
Pathways			Respiratory electron transport
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Autoimmune thyroid disease ( 32581359) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)	Huntington's disease progression ( 28642124)
Interacting Genes		11 interacting genes: AKT1 FCHSD2 GRB2 IFFO1 ITGB1 NEBL RABGAP1L SH3RF1 TFRC UQCRB VAMP3	9 interacting genes: ACAP1 ACCS HPCA HSPB1 LRRK2 MAGEA1 MAGEA4 MAGEB4 ZSWIM7
Entrez ID		9744	7381
HPRD ID		08474	11770
Ensembl ID		ENSG00000072818	ENSG00000156467
Uniprot IDs		Q15027	P14927
PDB IDs		3JUE 3T9K 4CKG 4CKH 4F1P 4NSW 5H3D	5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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