ACAP1 and FCHSD2

Data Source:
BioGRID (two hybrid)

		ACAP1	FCHSD2
Description		ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	FCH and double SH3 domains 2
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GO Annotations	Cellular Component	Membrane Recycling Endosome Membrane	Plasma Membrane Clathrin-coated Pit Neuromuscular Junction Recycling Endosome Stereocilium Shaft
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Protein Transport Positive Regulation Of GTPase Activity	Neuromuscular Synaptic Transmission Protein Transport Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Clathrin-dependent Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)	Albumin-globulin ratio ( 29403010) Crohn's disease ( 23850713 23266558) Endometrial cancer (endometrioid histology) ( 30093612) Health literacy ( 31250787) Nicotine dependence symptom count ( 25555482) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 26663301)
Interacting Genes		11 interacting genes: AKT1 FCHSD2 GRB2 IFFO1 ITGB1 NEBL RABGAP1L SH3RF1 TFRC UQCRB VAMP3	52 interacting genes: ABCF3 ACAP1 ANKS1A ATPAF2 BORCS6 C2orf73 C9orf78 CASK CCDC120 CCDC158 CCDC183 CCDC85B CCT2 CFAP36 CHKA CTAG1A CTAG1B DAPP1 ENKD1 FAM9B GPRASP2 HDAC4 HGS HOMER1 HSP90AB1 HSPA5 HTRA1 ITSN1 ITSN2 KIFC3 LCA5L LDOC1 MNS1 MRFAP1 MSL1 MTUS2 PDE4DIP PRKAR1B RINT1 SASS6 SERTAD3 SH2D4A SH3BGR SRP72 TLE5 TSGA10IP USHBP1 VCPIP1 VPS37C WAS WASL ZNF587
Entrez ID		9744	9873
HPRD ID		08474	13321
Ensembl ID		ENSG00000072818	ENSG00000137478
Uniprot IDs		Q15027	O94868
PDB IDs		3JUE 3T9K 4CKG 4CKH 4F1P 4NSW 5H3D	2DL5 2DL7 6GBU
Enriched GO Terms of Interacting Partners?
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