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MDC1 and RNF8
Data Source:
HPRD
(in vitro)
MDC1
RNF8
Description
mediator of DNA damage checkpoint 1
ring finger protein 8
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Focal Adhesion
Nuclear Body
Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Midbody
Site Of Double-strand Break
Molecular Function
Protein Binding
Protein C-terminus Binding
Identical Protein Binding
FHA Domain Binding
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Ubiquitin Protein Ligase Activity
Biological Process
Double-strand Break Repair Via Nonhomologous End Joining
Intra-S DNA Damage Checkpoint
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Cell Cycle
Spermatid Development
Response To Ionizing Radiation
Viral Process
Protein Ubiquitination
Histone H2A Ubiquitination
Histone H2B Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Spermatogenesis, Exchange Of Chromosomal Proteins
Interstrand Cross-link Repair
Histone Exchange
Isotype Switching
Positive Regulation Of DNA Repair
Cell Division
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Pathways
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
TP53 Regulates Transcription of DNA Repair Genes
G2/M DNA damage checkpoint
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Eosinophil counts (
31272903
)
Acne (severe) (
24927181
)
Restless legs syndrome (
29029846
)
Interacting Genes
40 interacting genes:
ANAPC1
ATM
BARD1
BDKRB1
BRCA1
CASP3
CENPC
CHEK2
COPS5
CREBBP
CSNK2A1
DTX2
EP300
GATA4
H2AX
HDAC10
HDAC8
HINFP
NBN
NCL
NSD2
PIAS1
PIAS4
PRIM1
RAD50
RAD51
RNF8
SMC1A
SRPK2
SUMO2
TNKS2
TP53
TP53BP1
UIMC1
USP13
USP15
USP28
VAMP5
WRN
ZNF251
76 interacting genes:
AMOTL2
BLM
C2CD6
CALCOCO1
CCDC14
CCDC50
CCDC85B
CEP44
CEP85
CHD4
CHEK2
CLK2
CLK3
DNM2
DNTTIP2
EPN2
EPN3
EXOSC2
FAM9B
FSD2
GPRASP2
H2AC20
H2AX
H2BC21
H2BC3
H3-3B
HOMEZ
JMJD1C
KDM4A
KIF24
KRTAP10-1
KRTAP10-8
KRTAP9-2
KRTAP9-8
LMO4
MAD1L1
MAGED1
MAPK1
MDC1
MDM2
PCNA
PCYT1A
PGRMC2
PICK1
PNMA2
POLD4
PSMB1
RBFOX2
RXRA
RYBP
SCN3B
SEPTIN3
SH3GL3
STX11
SUMO2
SUMO3
TMEM79
TNIP1
TOMM20L
TRIM29
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2V2
UBE2W
VCP
WASL
YEATS4
ZBTB10
ZNF346
ZNF496
Entrez ID
9656
9025
HPRD ID
16252
11521
Ensembl ID
ENSG00000137337
ENSG00000112130
Uniprot IDs
A0A1U9XBC1
A1Z5I9
Q14676
O76064
PDB IDs
2ADO
2AZM
2ETX
3K05
3UEO
3UMZ
3UN0
3UNM
3UNN
3UOT
2CSW
2PIE
4AYC
4ORH
4WHV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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