MDC1 and HDAC10

Data Source:
BioGRID (unspecified method)

		MDC1	HDAC10
Description		mediator of DNA damage checkpoint 1	histone deacetylase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding	Histone Deacetylase Activity Protein Binding Zinc Ion Binding Deacetylase Activity Enzyme Binding Protein Deacetylase Activity Histone Deacetylase Binding Acetylputrescine Deacetylase Activity Acetylspermidine Deacetylase Activity
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Chromatin Organization Regulation Of Transcription, DNA-templated Protein Deacetylation Oligodendrocyte Development Macroautophagy Histone Deacetylation Positive Regulation Of Mismatch Repair Peptidyl-lysine Deacetylation Homologous Recombination Negative Regulation Of Transcription, DNA-templated Polyamine Deacetylation Spermidine Deacetylation
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs			Belinostat Panobinostat Bufexamac
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)	Acne (severe) ( 24927181) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		40 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251	9 interacting genes: HDAC2 HDAC3 HSPA8 MDC1 MTNR1A NCOR2 PAX3 TRIM28 TRIM54
Entrez ID		9656	83933
HPRD ID		16252	09407
Ensembl ID		ENSG00000137337	ENSG00000100429
Uniprot IDs		A0A1U9XBC1 A1Z5I9 Q14676	Q969S8
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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