MDC1 and HDAC8

Data Source:
BioGRID (unspecified method)

		MDC1	HDAC8
Description		mediator of DNA damage checkpoint 1	histone deacetylase 8
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding	Histone Deacetylase Activity Protein Binding Transcription Factor Binding Hsp70 Protein Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Metal Ion Binding Hsp90 Protein Binding
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Assembly Or Disassembly Sister Chromatid Cohesion Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Telomere Maintenance Positive Regulation Of Transcription By RNA Polymerase II Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Cohesin Loading
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway
Drugs			Iron Zinc Vorinostat 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide Trichostatin A Belinostat Panobinostat (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE Coumarin 120 Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)	Chloride levels ( 29403010) Sodium levels ( 29403010)
Interacting Genes		40 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251	9 interacting genes: ESRRA H3-4 H3C1 H4-16 H4C1 MDC1 PRKACA RTN1 RUNX1T1
Entrez ID		9656	55869
HPRD ID		16252	02227
Ensembl ID		ENSG00000137337	ENSG00000147099
Uniprot IDs		A0A1U9XBC1 A1Z5I9 Q14676	Q9BY41
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT	1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH 4QA0 4QA1 4QA2 4QA3 4QA4 4QA5 4QA6 4QA7 4RN0 4RN1 4RN2 5BWZ 5D1B 5D1C 5D1D 5DC5 5DC6 5DC7 5DC8 5FCW 5THS 5THT 5THU 5THV 5VI6 6HSK 6ODA 6ODB 6ODC
Enriched GO Terms of Interacting Partners?
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