RNF8 and EXOSC2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RNF8	EXOSC2
Description		ring finger protein 8	exosome component 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Viral Process Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		76 interacting genes: AMOTL2 BLM C2CD6 CALCOCO1 CCDC14 CCDC50 CCDC85B CEP44 CEP85 CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A KIF24 KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 PCNA PCYT1A PGRMC2 PICK1 PNMA2 POLD4 PSMB1 RBFOX2 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4 ZBTB10 ZNF346 ZNF496	18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408
Entrez ID		9025	23404
HPRD ID		11521	03758
Ensembl ID		ENSG00000112130	ENSG00000130713
Uniprot IDs		O76064	B3KQW2 Q13868
PDB IDs		2CSW 2PIE 4AYC 4ORH 4WHV	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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