RNF8 and SCN3B

Data Source:
BioGRID (two hybrid)

		RNF8	SCN3B
Description		ring finger protein 8	sodium voltage-gated channel beta subunit 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity	Voltage-gated Ion Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Viral Process Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination	Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases			Brugada syndrome (BRS)
GWAS		Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)	Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Response to citalopram or escitalopram in depression ( 27622933)
Interacting Genes		76 interacting genes: AMOTL2 BLM C2CD6 CALCOCO1 CCDC14 CCDC50 CCDC85B CEP44 CEP85 CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A KIF24 KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 PCNA PCYT1A PGRMC2 PICK1 PNMA2 POLD4 PSMB1 RBFOX2 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4 ZBTB10 ZNF346 ZNF496	105 interacting genes: ADIPOQ AGPAT4 AGPAT5 ANKRD46 AQP10 ARV1 ATP13A1 ATP6V0C BNIP1 BNIP3 BRICD5 CLCA4 CTXN3 CYP4F2 DEFB103A DEFB103B DERL1 DGAT2L6 ERG28 FAM241B FAM3C FIS1 FKBP8 FXYD3 GIMAP1 GIMAP5 GPR151 GPR61 IER3IP1 INSIG2 ISM2 ITGAM LEMD1 LEPROTL1 LPAR3 MAL2 MARCHF2 MFSD5 MGST3 MS4A13 NFASC NINJ2 ORMDL1 ORMDL2 PLBD2 PLP2 PLPPR2 PMP22 RHD RNF8 RUSF1 SACM1L SCD SEC22A SERP2 SFT2D1 SFXN1 SFXN3 SLC2A5 SLC30A3 SLC30A8 SLC35A4 SLC35E4 SLC38A1 SLC38A7 SLC7A1 SMCO4 SMIM1 STRIT1 STX3 STX6 STX8 THSD7A TIMM23 TM6SF2 TMBIM6 TMEM120A TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM208 TMEM239 TMEM243 TMEM42 TMEM50B TMEM60 TMEM65 TMEM86A TMPPE TPRG1 TRARG1 TSPAN2 TVP23B UBIAD1 USE1 VAMP1 VAMP2 VAMP3 VAPA VAPB YIF1A YIPF4 ZFPL1
Entrez ID		9025	55800
HPRD ID		11521	10497
Ensembl ID		ENSG00000112130	ENSG00000166257
Uniprot IDs		O76064	A0A024R3H7 Q9NY72
PDB IDs		2CSW 2PIE 4AYC 4ORH 4WHV	4L1D
Enriched GO Terms of Interacting Partners?
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