CIR1 and SRSF2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CIR1	SRSF2
Description		corepressor interacting with RBPJ, CIR1	serine and arginine rich splicing factor 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Nuclear Speck
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding	Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development MRNA Processing RNA Splicing Negative Regulation Of Transcription, DNA-templated	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Negative Regulation Of Transcription, DNA-templated
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) ( 29899525) Adult body size ( 32376654) Chronotype ( 30696823) Hand grip strength ( 29691431) Triglyceride levels ( 32203549)
Interacting Genes		14 interacting genes: CCDC33 CEP76 DPPA4 HDAC2 MB21D2 NCOR2 NEK6 RBPJ RP9 SAP30 SNW1 SRSF2 TCEA1 U2AF1	34 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRPK2 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2
Entrez ID		9541	6427
HPRD ID		05568	02888
Ensembl ID		ENSG00000138433	ENSG00000161547
Uniprot IDs		Q86X95	A0A024R8U5 Q01130 Q53FN0
PDB IDs		6ZYM	2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?
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