CIR1 and U2AF1

Data Source:
BioGRID (pull down)

		CIR1	U2AF1
Description		corepressor interacting with RBPJ, CIR1	U2 small nuclear RNA auxiliary factor 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Nuclear Speck Protein-containing Complex	Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding	RNA Binding Protein Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development MRNA Processing RNA Splicing Negative Regulation Of Transcription, DNA-templated	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) ( 29899525) Adult body size ( 32376654) Chronotype ( 30696823) Hand grip strength ( 29691431) Triglyceride levels ( 32203549)	Blood and toenail selenium levels ( 25343990)
Interacting Genes		14 interacting genes: CCDC33 CEP76 DPPA4 HDAC2 MB21D2 NCOR2 NEK6 RBPJ RP9 SAP30 SNW1 SRSF2 TCEA1 U2AF1	51 interacting genes: AP1B1 AP2B1 CARNMT1 CHERP CIR1 CLK2 DHX38 EFHC2 EPB41 FRA10AC1 HINFP HNRNPK HNRNPM IL7R JMJD6 KRT1 KRT75 MAP1B MEOX2 MFAP1 MLH1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A PTEN RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRNP35 SNRPD1 SRPK1 SRRM4 SRSF1 SRSF2 SRSF3 SUV39H1 TOE1 TRA2B U2AF2 VEGFA ZCCHC10 ZNF417 ZRANB2 ZRSR2
Entrez ID		9541	7307
HPRD ID		05568	01871
Ensembl ID		ENSG00000138433	ENSG00000160201
Uniprot IDs		Q86X95	P0DN76 Q01081 Q7Z780
PDB IDs		6ZYM	1JMT
Enriched GO Terms of Interacting Partners?
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