CIR1 and NCOR2

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		CIR1	NCOR2
Description		corepressor interacting with RBPJ, CIR1	nuclear receptor corepressor 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Nuclear Speck Protein-containing Complex	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Membrane Nuclear Matrix Nuclear Body Transcription Repressor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Notch Binding Protein Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Protein-containing Complex Binding Retinoid X Receptor Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development MRNA Processing RNA Splicing Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Lactation Response To Organonitrogen Compound Regulation Of Cellular Ketone Metabolic Process Regulation Of Lipid Metabolic Process Response To Estradiol Estrous Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Pathways			PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) ( 29899525) Adult body size ( 32376654) Chronotype ( 30696823) Hand grip strength ( 29691431) Triglyceride levels ( 32203549)	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Appendicular lean mass ( 33097823) Clubfoot ( 24667120) Cocaine dependence ( 23958962) Cognitive performance ( 19734545) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Height ( 31562340) Lung function (FEV1) ( 30061609) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: CCDC33 CEP76 DPPA4 HDAC2 MB21D2 NCOR2 NEK6 RBPJ RP9 SAP30 SNW1 SRSF2 TCEA1 U2AF1	89 interacting genes: ADRB2 AHR AKT1 AP2M1 AR ARNT ATXN1 ATXN1L BCL6 C1D CBFA2T2 CDK2 CEBPB CEP63 CHUK CIR1 CNOT2 DDX20 E2F1 ESR1 ESR2 FOS FOXP1 H4C1 HDAC1 HDAC10 HDAC3 HDAC4 HDAC5 HDAC7 HNF4A INPP5K IRF5 JUN KLF5 MYBL2 MYOD1 NCOA3 NCOA6 NCOR1 NFE2L2 NFKB1 NFKBIA NFKBIB NFKBIE NR1D1 NR1H2 NR1H4 NR1I2 NR2F1 NR2F2 NR3C1 NR4A1 PIN1 PML POU2F1 PPARA PPARD PPARG RANBP9 RARA RARB RARG RBPJ RELA RUNX1 RUNX1T1 RXRA RXRG SAP30 SIN3A SKIL SNW1 SP1 SPEN SRF STAT5A STAT5B SUMO1 TBL1X THRA THRB TNIK TNIP2 UBE2I VDR YWHAE ZBTB16 ZBTB7A
Entrez ID		9541	9612
HPRD ID		05568	02910
Ensembl ID		ENSG00000138433	ENSG00000196498
Uniprot IDs		Q86X95	C9J0Q5 C9JE98 Q9Y618
PDB IDs		6ZYM	1KKQ 1R2B 1XC5 2GPV 2L5G 2LTP 2ODD 2RT5 3R29 3R2A 4A69 4OAR 5X8Q 5X8X 5ZOO 5ZOP 6A22 6IVX 6PDZ
Enriched GO Terms of Interacting Partners?
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