SRSF2 and UBQLN4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SRSF2	UBQLN4
Description		serine and arginine rich splicing factor 2	ubiquilin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Protein-containing Complex Perinuclear Region Of Cytoplasm Site Of DNA Damage
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Negative Regulation Of Transcription, DNA-templated	DNA Repair Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Autophagosome Maturation Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		34 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRPK2 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2	161 interacting genes: ADAM33 ADPGK AGR2 ANKRD13D AREG ARL4C ATP5IF1 ATP5MK ATXN1 BAG6 BPIFA1 C11orf49 C1orf94 C1QTNF1 CACNA1G CCDC107 CCDC134 CCDC136 CCDC14 CCDC33 CCL21 CD99 CDSN CEND1 COL8A1 COPB1 CPSF6 CRIPT CSTF2 CSTF2T CTSB CYB5R1 DAZAP2 DKK3 DMPK DNAJB11 DTX2 EAPP EDN1 EEF1A1 EFEMP2 ELF5 EPDR1 ERP27 ERP29 FA2H FGFBP1 FKBP2 FKBP7 FZD7 GABRD GDI1 GJA1 GJA5 GJC1 GKAP1 GPX7 HAVCR1 HGS HK2 HSPA13 HSPA5 IGFBP6 IGHM IGLC1 IMMT IMPDH2 ITPRIPL1 KLHL26 KLHL42 LAT2 MDK MDM2 MIEF2 MIF4GD MLLT6 MOAP1 MTNR1B MYDGF NAE1 NME3 NOMO1 NOMO3 NOTCH2NLA NPHP1 NPPA NXF1 OAT ORC5 PBXIP1 PCDH17 PCDH8 PDIA5 PDLIM7 PELI2 PICK1 PIN1 PIP4K2B PLAAT3 PMEPA1 PNMA1 PPIB PPIC PRL PRPF40A PTN PTPRN PTPRN2 QSOX1 RAD23A RAI2 RBM10 RIC8A RNF11 RNPS1 ROBO2 RPN1 RSRC2 RUNX1T1 RXRA SCAF1 SCG2 SCG5 SCMH1 SEMG1 SERPINE1 SERPINH1 SERPINI2 SMAD3 SMAD9 SMARCB1 SPAG8 SPINT1 SPP1 SRGN SRSF2 STAM2 STMN1 SUPT20H TFF1 TGFB1I1 TNFRSF14 TNRC6B TRAF2 TRIB2 TRIM32 UBC UBQLN1 UBQLN2 UBR7 UNC119 UROS VIP WAC YWHAQ ZBTB22 ZDHHC3 ZFPM2 ZG16 ZG16B ZNF205
Entrez ID		6427	56893
HPRD ID		02888	05670
Ensembl ID		ENSG00000161547	ENSG00000160803
Uniprot IDs		A0A024R8U5 Q01130 Q53FN0	B4DZF6 Q59F94 Q9NRR5
PDB IDs		2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?
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