EPN1 and REPS2

Data Source:
HPRD (in vivo, in vitro)

		EPN1	REPS2
Description		epsin 1	RALBP1 associated Eps domain containing 2
Image
GO Annotations	Cellular Component	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding	Calcium Ion Binding Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Endosomal Transport Membrane Organization Protein-containing Complex Assembly
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Major depressive disorder ( 23377640)
Interacting Genes		25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16	13 interacting genes: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 PXN RALB RALBP1 RELA REPS1
Entrez ID		29924	9185
HPRD ID		06270	02262
Ensembl ID		ENSG00000063245	ENSG00000169891
Uniprot IDs		A0A024R4S1 Q9Y6I3	Q8NFH8
PDB IDs		1INZ 1KYD	1IQ3
Enriched GO Terms of Interacting Partners?
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