NEK9 and BICD2

Data Source:
HPRD (in vitro, in vivo)

		NEK9	BICD2
Description		NIMA related kinase 9	BICD cargo adaptor 2
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nuclear Envelope Annulate Lamellae Nuclear Pore Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Cytoskeletal Anchor Activity Small GTPase Binding Dynactin Binding Dynein Light Intermediate Chain Binding Dynein Complex Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Protein Transport Protein Localization To Organelle Protein Localization To Golgi Apparatus MRNA Transport Centrosome Localization Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	COPI-independent Golgi-to-ER retrograde traffic
Drugs		Fostamatinib
Diseases
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)	Height ( 31562340) Malaria ( 31844061) Neutrophil count ( 32888494) Platelet count ( 32888494) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN	42 interacting genes: ARHGAP45 CBR3 CCDC187 CCHCR1 DCTN1 DCTN2 DCX FAM110A FAM161A FAM161B FAM50B GSK3B HDAC4 LNX1 MFAP1 MOS NEK9 PMF1 POLDIP3 PPP1R18 PRPF18 PRPF31 RAB6A RAB6B RBM41 SNW1 TBRG4 TCEA2 TCEANC TSGA10IP USP2 UTP14C YES1 ZC2HC1C ZMAT2 ZNF417 ZNF624 ZNF648 ZNF669 ZNF670 ZSCAN12 ZSCAN23
Entrez ID		91754	23299
HPRD ID		11386	09826
Ensembl ID		ENSG00000119638	ENSG00000185963
Uniprot IDs		Q6PKF2 Q8TD19	Q8TD16 Q96FU2
PDB IDs		3ZKE 3ZKF	6OFP 6PSE
Enriched GO Terms of Interacting Partners?
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