NEK9 and SSRP1

Data Source:
HPRD (in vivo)

		NEK9	SSRP1
Description		NIMA related kinase 9	structure specific recognition protein 1
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleoplasm Nucleolus FACT Complex
	Molecular Function	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division	DNA Replication DNA Repair Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Chromatin Organization
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs		Fostamatinib
Diseases
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN	22 interacting genes: AURKA CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AC20 H2AX H2BC21 H3-3A MCM4 MYCBP NEK9 PTEN RAN ROBO2 SPI1 SREK1 SRF SUMO2 SUPT16H UBE2I
Entrez ID		91754	6749
HPRD ID		11386	05061
Ensembl ID		ENSG00000119638	ENSG00000149136
Uniprot IDs		Q6PKF2 Q8TD19	A0A024R4Z6 Q08945
PDB IDs		3ZKE 3ZKF	4IFS 5UMR 5UMS 5VWE 6L1E 6L1R 6L34 6UPK 6UPL
Enriched GO Terms of Interacting Partners?
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