BICD2 and NEK9

Data Source:
HPRD (in vitro, in vivo)

		BICD2	NEK9
Description		BICD cargo adaptor 2	NIMA related kinase 9
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GO Annotations	Cellular Component	Nuclear Envelope Annulate Lamellae Nuclear Pore Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cytoplasmic Vesicle	Nucleus Centrosome Cytosol
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Small GTPase Binding Dynactin Binding Dynein Light Intermediate Chain Binding Dynein Complex Binding	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Protein Transport Protein Localization To Organelle Protein Localization To Golgi Apparatus MRNA Transport Centrosome Localization Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division
Pathways		COPI-independent Golgi-to-ER retrograde traffic	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Height ( 31562340) Malaria ( 31844061) Neutrophil count ( 32888494) Platelet count ( 32888494) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) White blood cell count ( 32888494)	Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		42 interacting genes: ARHGAP45 CBR3 CCDC187 CCHCR1 DCTN1 DCTN2 DCX FAM110A FAM161A FAM161B FAM50B GSK3B HDAC4 LNX1 MFAP1 MOS NEK9 PMF1 POLDIP3 PPP1R18 PRPF18 PRPF31 RAB6A RAB6B RBM41 SNW1 TBRG4 TCEA2 TCEANC TSGA10IP USP2 UTP14C YES1 ZC2HC1C ZMAT2 ZNF417 ZNF624 ZNF648 ZNF669 ZNF670 ZSCAN12 ZSCAN23	10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN
Entrez ID		23299	91754
HPRD ID		09826	11386
Ensembl ID		ENSG00000185963	ENSG00000119638
Uniprot IDs		Q8TD16 Q96FU2	Q6PKF2 Q8TD19
PDB IDs		6OFP 6PSE	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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