NEK9 and NEK8

Data Source:
BioGRID (enzymatic study)

		NEK9	NEK8
Description		NIMA related kinase 9	NIMA related kinase 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleus Cytoplasm Centrosome Cilium Ciliary Inversin Compartment Ciliary Base
	Molecular Function	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division	Protein Phosphorylation Chromosome Segregation Determination Of Left/right Symmetry Heart Development Animal Organ Morphogenesis Regulation Of Hippo Signaling
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)	Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN	11 interacting genes: ACVR1 ADAMTSL4 KRTAP13-2 NEK9 OXER1 RGS20 TCF4 TGFBR1 TRIM42 TRIM69 UBC
Entrez ID		91754	284086
HPRD ID		11386	14822
Ensembl ID		ENSG00000119638	ENSG00000160602
Uniprot IDs		Q6PKF2 Q8TD19	Q86SG6
PDB IDs		3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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