SPAG9 and MAP3K3

Data Source:
HPRD (in vitro)

		SPAG9	MAP3K3
Description		sperm associated antigen 9	mitogen-activated protein kinase kinase kinase 3
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Lysosomal Membrane Cytosol Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity Identical Protein Binding	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Activation Of JUN Kinase Activity Vesicle-mediated Transport Positive Regulation Of Cell Migration Lysosome Localization Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Dendrite Extension	MAPK Cascade Activation Of MAPKK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence
Pathways		Myogenesis Myogenesis	Interleukin-1 signaling
Drugs			Fostamatinib
Diseases
GWAS		Body fat mass ( 28552196) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)	Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951)
Interacting Genes		12 interacting genes: ARF6 KLC1 MAP1LC3B MAP2K4 MAP3K3 MAPK14 MAPK8 MAX MYC NFKB1 PNRC2 TP53BP1	42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16
Entrez ID		9043	4215
HPRD ID		10398	03965
Ensembl ID		ENSG00000008294	ENSG00000198909
Uniprot IDs		O60271 Q5JB53	J3KRN4 Q96HN9 Q99759
PDB IDs		2W83	2C60 2JRH 2O2V 2PPH 4Y5O 4YL6
Enriched GO Terms of Interacting Partners?
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