SPAG9 and PNRC2

Data Source:
BioGRID (two hybrid)

		SPAG9	PNRC2
Description		sperm associated antigen 9	proline rich nuclear receptor coactivator 2
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Lysosomal Membrane Cytosol Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome	P-body Nucleus Nucleoplasm Golgi Apparatus Cytosol
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Signaling Receptor Complex Adaptor Activity Identical Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Activation Of JUN Kinase Activity Vesicle-mediated Transport Positive Regulation Of Cell Migration Lysosome Localization Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Negative Regulation Of Dendrite Extension	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Myogenesis Myogenesis	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)	Obesity-related traits ( 23251661)
Interacting Genes		12 interacting genes: ARF6 KLC1 MAP1LC3B MAP2K4 MAP3K3 MAPK14 MAPK8 MAX MYC NFKB1 PNRC2 TP53BP1	23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		9043	55629
HPRD ID		10398	17871
Ensembl ID		ENSG00000008294	ENSG00000189266
Uniprot IDs		O60271 Q5JB53	Q9NPJ4
PDB IDs		2W83	4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?
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