MAP3K3 and HSPA2

Data Source:
HPRD (in vivo)

		MAP3K3	HSPA2
Description		mitogen-activated protein kinase kinase kinase 3	heat shock protein family A (Hsp70) member 2
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GO Annotations	Cellular Component	Cytosol	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane CatSper Complex Extracellular Exosome Blood Microparticle Meiotic Spindle
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Protein Folding Chaperone Tau Protein Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding Glycolipid Binding Disordered Domain Specific Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence	Positive Regulation Of Protein Phosphorylation Response To Unfolded Protein Male Meiotic Nuclear Division Male Meiosis I Spermatogenesis Spermatid Development Response To Heat Response To Cold Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Positive Regulation Of ATPase Activity Cellular Response To Unfolded Protein Protein Refolding Chaperone Cofactor-dependent Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
Pathways		Interleukin-1 signaling	Meiotic synapsis Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase
Drugs		Fostamatinib	Quercetin
Diseases
GWAS		Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951)
Interacting Genes		42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	10 interacting genes: APP BAG4 CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38
Entrez ID		4215	3306
HPRD ID		03965	07174
Ensembl ID		ENSG00000198909	ENSG00000126803
Uniprot IDs		J3KRN4 Q96HN9 Q99759	A0A024R6B5 P54652
PDB IDs		2C60 2JRH 2O2V 2PPH 4Y5O 4YL6	3I33 4FSV 5FPD 5FPE 5FPM 5FPN
Enriched GO Terms of Interacting Partners?
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