MAP3K3 and PFDN2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MAP3K3	PFDN2
Description		mitogen-activated protein kinase kinase kinase 3	prefoldin subunit 2
Image
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Mitochondrion Cytosol Prefoldin Complex
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence	Protein Folding Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Amyloid Fibril Formation
Pathways		Interleukin-1 signaling	Prefoldin mediated transfer of substrate to CCT/TriC
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951)
Interacting Genes		42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	9 interacting genes: DBI ERBB3 MAP3K3 PFDN1 PFDN4 PFDN5 SNCA VBP1 ZNF726
Entrez ID		4215	5202
HPRD ID		03965	09658
Ensembl ID		ENSG00000198909	ENSG00000143256
Uniprot IDs		J3KRN4 Q96HN9 Q99759	B1AQP2 Q9UHV9
PDB IDs		2C60 2JRH 2O2V 2PPH 4Y5O 4YL6	6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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