MAP3K3 and RCAN1

Data Source:
HPRD (in vivo)

		MAP3K3	RCAN1
Description		mitogen-activated protein kinase kinase kinase 3	regulator of calcineurin 1
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GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Nucleic Acid Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence	Calcium-mediated Signaling Calcineurin-NFAT Signaling Cascade Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Interleukin-1 signaling
Drugs		Fostamatinib	Dipyridamole
Diseases
GWAS		Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951)	Cancer ( 29299148) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16	8 interacting genes: APP BTRC GSK3B MAP3K3 MAPK3 PPP3CA USP22 UXT
Entrez ID		4215	1827
HPRD ID		03965	04226
Ensembl ID		ENSG00000198909	ENSG00000159200
Uniprot IDs		J3KRN4 Q96HN9 Q99759	B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9
PDB IDs		2C60 2JRH 2O2V 2PPH 4Y5O 4YL6	6UUQ
Enriched GO Terms of Interacting Partners?
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