BCL10 and SOCS3

Data Source:
HPRD (in vivo)

		BCL10	SOCS3
Description		BCL10 immune signaling adaptor	suppressor of cytokine signaling 3
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Polkadots Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Kinase B Binding Protein Self-association Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	B Cell Apoptotic Process Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Cell Death Response To Fungus Immunoglobulin Mediated Immune Response Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Protein Kinase Activity Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Interleukin-6-mediated Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins	Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)	Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)
Interacting Genes		46 interacting genes: AKT1 ANP32B ATM BAAT BIRC3 CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1	63 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ
Entrez ID		8915	9021
HPRD ID		04625	05006
Ensembl ID		ENSG00000142867	ENSG00000184557
Uniprot IDs		A0A087WWW9 A2TDT2 O95999	O14543 Q6FI39
PDB IDs		2MB9 6BZE 6GK2
Enriched GO Terms of Interacting Partners?
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