SOCS3 and RNF31

Data Source:
BioGRID (two hybrid)

		SOCS3	RNF31
Description		suppressor of cytokine signaling 3	ring finger protein 31
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex LUBAC Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Interleukin-6-mediated Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Linear Polyubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway
Drugs
Diseases
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Suicide behavior ( 26079190)
Interacting Genes		63 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	46 interacting genes: ATN1 ATXN1 ATXN7 AZI2 CCDC24 CDC34 GFI1B HDAC6 KIF1A KRTAP9-2 NOS3 NR0B1 NR0B2 PITX1 PRKCA RBCK1 SEPTIN2 SMAD3 SNRPC SOCS3 SPATA2 STK4 TLE5 TRAF1 TRAF6 TRIM25 TSSC4 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2T UBE2W VASN VDAC1
Entrez ID		9021	55072
HPRD ID		05006	11516
Ensembl ID		ENSG00000184557	ENSG00000092098
Uniprot IDs		O14543 Q6FI39	Q96EP0
PDB IDs			2CT7 4DBG 4JUY 4LJO 4LJP 4LJQ 4OWF 4OYJ 4OYK 4P09 4P0A 4P0B 5EDV 5LJN 5X0W 6GZY 6KC5 6KC6 6SC5 6SC6 6SC7 6SC8 6SC9
Enriched GO Terms of Interacting Partners?
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