SOCS3 and IL12RB2

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SOCS3	IL12RB2
Description		suppressor of cytokine signaling 3	interleukin 12 receptor subunit beta 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Cytokine Receptor Activity Cytokine Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Interleukin-6-mediated Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs
Diseases
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576 29875488) Crohn's disease ( 28067908 22412388) Crohn's disease or systemic sclerosis ( 32024964) Inflammatory bowel disease ( 28067908 23128233) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 19458352 21399635 20639880 26394269) Rheumatoid arthritis ( 32868391) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Systemic lupus erythematosus ( 33536424 26502338 28714469 19838195) Systemic sclerosis ( 31672989 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 28067908)
Interacting Genes		63 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		9021	3595
HPRD ID		05006	03383
Ensembl ID		ENSG00000184557	ENSG00000081985
Uniprot IDs		O14543 Q6FI39	A0A0A0MTN7 B4DGA4 B7ZB60 Q99665
PDB IDs
Enriched GO Terms of Interacting Partners?
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