SOCS3 and MAP1S

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SOCS3	MAP1S
Description		suppressor of cytokine signaling 3	microtubule associated protein 1S
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Nucleus Nucleoplasm Nucleolus Spindle Cytosol Microtubule Microtubule Associated Complex Cell Junction Dendrite Cell Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	DNA Binding Actin Binding Deoxyribonuclease Activity Protein Binding Microtubule Binding Tubulin Binding Beta-tubulin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Interleukin-6-mediated Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Microtubule Cytoskeleton Organization Microtubule Bundle Formation DNA Metabolic Process Autophagy Apoptotic Process Nervous System Development Axonogenesis Brain Development Regulation Of Chromatin Disassembly Dendrite Development Regulation Of Microtubule Depolymerization Mitochondrion Transport Along Microtubule Neuron Projection Morphogenesis
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Coronary artery disease ( 29212778 33020668) Height ( 28552196)
Interacting Genes		63 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	12 interacting genes: ATM BPY2 BPY2C HDAC4 LRPPRC MAP1LC3A NLGN3 PIN1 RASSF1 SLC2A4 SOCS3 SRPK2
Entrez ID		9021	55201
HPRD ID		05006	10461
Ensembl ID		ENSG00000184557	ENSG00000130479
Uniprot IDs		O14543 Q6FI39	Q66K74
PDB IDs
Enriched GO Terms of Interacting Partners?
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