SOCS3 and TFR2

Data Source:
BioGRID (two hybrid)

		SOCS3	TFR2
Description		suppressor of cytokine signaling 3	transferrin receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Transferrin Receptor Activity Protein Binding Co-receptor Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Receptor Signaling Pathway Via JAK-STAT Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Interleukin-6-mediated Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Iron Ion Transport Cellular Iron Ion Homeostasis Receptor-mediated Endocytosis Acute-phase Response Response To Iron Ion Transferrin Transport Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Endocytic Iron Import Into Cell Positive Regulation Of Protein Maturation
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Transferrin endocytosis and recycling
Drugs			Ferrous sulfate anhydrous Ferric derisomaltose
Diseases			Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Asthma ( 32296059) Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Apolipoprotein B levels ( 32203549) Eosinophil counts ( 32888494) Hematocrit ( 32888494 27863252 28017375 19862010) Hematological parameters ( 19820697) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Iron status biomarkers ( 21208937) Iron status biomarkers (iron levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010 32888494 28453575 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		63 interacting genes: ABL1 ACADVL APP AR BCL10 BIK BLK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR ERBB2 ERBB3 ERBB4 GAB1 GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 KIT LEPR MAP1S MAPK11 MAPK6 MET NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXK TXNDC11 YES1 YWHAQ	5 interacting genes: HFE OLFM4 SEC22A SOCS3 TF
Entrez ID		9021	7036
HPRD ID		05006	05282
Ensembl ID		ENSG00000184557	ENSG00000106327
Uniprot IDs		O14543 Q6FI39	Q9UP52
PDB IDs
Enriched GO Terms of Interacting Partners?
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