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CCNA1 and RBL1
Data Source:
HPRD
(in vivo, in vitro)
CCNA1
RBL1
Description
cyclin A1
RB transcriptional corepressor like 1
Image
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Chromatin
Nucleoplasm
Transcription Regulator Complex
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Protein Binding
Transcription Factor Binding
Promoter-specific Chromatin Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Cell Cycle
Negative Regulation Of Gene Expression
Viral Process
Cell Differentiation
Regulation Of Lipid Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Division
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cellular Senescence
Pathways
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
G1/S-Specific Transcription
Cyclin D associated events in G1
Drugs
Diseases
GWAS
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Height (
25429064
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
28957414
)
Interacting Genes
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
54 interacting genes:
AOX1
BEGAIN
BRCA1
BRF1
CCNA1
CCNA2
CCND1
CCNE1
CDK2
CDK4
CDK6
CEBPA
CREG1
DGKZ
DHX30
DYRK1A
E2F1
E2F4
E2F5
EPHA2
FN1
GOLGA2
HDAC1
ID2
IRF3
KDM5A
KMT5C
LAMB2
MAPK6
MCM7
MYBL2
MYC
NR2E3
NR4A1
NUCB1
PHB
PLSCR1
PPP2R3A
RBBP8
RBBP9
RINT1
SMAD2
SMAD3
SMAD4
SMARCA4
SNRPD3
SNW1
SP1
SUV39H1
TAF1
TOP1
TP53BP1
TSC22D2
USP4
Entrez ID
8900
5933
HPRD ID
04946
00312
Ensembl ID
ENSG00000133101
ENSG00000080839
Uniprot IDs
A0A140VJG0
P78396
P28749
PDB IDs
1H28
4YOO
4YOS
4YOZ
5TUV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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