RBL1 and AOX1

Data Source:
BioGRID (two hybrid)

		RBL1	AOX1
Description		RB transcriptional corepressor like 1	aldehyde oxidase 1
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Transcription Factor Binding Promoter-specific Chromatin Binding	Aldehyde Oxidase Activity Iron Ion Binding Electron Transfer Activity Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding NAD Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding Geranial:oxygen Oxidoreductase Activity Heptaldehyde:oxygen Oxidoreductase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence	Drug Metabolic Process Electron Transport Chain Vitamin B6 Metabolic Process
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1	Vitamins B6 activation to pyridoxal phosphate
Drugs			Cyclobenzaprine Eniluracil
Diseases			Xanthinuria
GWAS		Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)	Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		54 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4	6 interacting genes: ABCA1 CRKL ERRFI1 GK RBL1 RCHY1
Entrez ID		5933	316
HPRD ID		00312	07537
Ensembl ID		ENSG00000080839	ENSG00000138356
Uniprot IDs		P28749	Q06278
PDB IDs		1H28 4YOO 4YOS 4YOZ 5TUV	4UHW 4UHX 5EPG 6Q6Q
Enriched GO Terms of Interacting Partners?
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