CCNA1 and ARID2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		CCNA1	ARID2
Description		cyclin A1	AT-rich interaction domain 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Cytoskeleton Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex	Nucleoplasm Plasma Membrane
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Male Meiosis I Spermatogenesis Protein Deubiquitination Mitotic Cell Cycle Phase Transition Cell Division	Heart Morphogenesis Nucleosome Disassembly Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Homeostatic Process Embryonic Organ Development Cardiac Muscle Cell Proliferation Coronary Artery Morphogenesis Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Telomere Extension By Telomerase Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Cocaine dependence ( 31212010) Nickel levels ( 26025379)	Chronotype ( 30696823) Fish- and plant-related diet ( 32066663) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hippocampal atrophy ( 19668339) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Morning person ( 30696823) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		35 interacting genes: ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6	6 interacting genes: CCNA1 NFYC SMARCA4 SMARCE1 SUMO2 TSC22D2
Entrez ID		8900	196528
HPRD ID		04946	16505
Ensembl ID		ENSG00000133101	ENSG00000189079
Uniprot IDs		A0A140VJG0 P78396	Q68CP9
PDB IDs
Enriched GO Terms of Interacting Partners?
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