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CCNA1 and ARID2
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
CCNA1
ARID2
Description
cyclin A1
AT-rich interaction domain 2
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Nucleoplasm
Plasma Membrane
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
DNA Binding
Protein Binding
Metal Ion Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
Heart Morphogenesis
Nucleosome Disassembly
Regulation Of Transcription, DNA-templated
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Migration
Homeostatic Process
Embryonic Organ Development
Cardiac Muscle Cell Proliferation
Coronary Artery Morphogenesis
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Chronotype (
30696823
)
Fish- and plant-related diet (
32066663
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hippocampal atrophy (
19668339
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
)
Morning person (
30696823
)
PR interval (
32439900
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Triglyceride levels (
32203549
)
Triglycerides (
30275531
)
Interacting Genes
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
6 interacting genes:
CCNA1
NFYC
SMARCA4
SMARCE1
SUMO2
TSC22D2
Entrez ID
8900
196528
HPRD ID
04946
16505
Ensembl ID
ENSG00000133101
ENSG00000189079
Uniprot IDs
A0A140VJG0
P78396
Q68CP9
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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