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CCNA1 and PGR
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
CCNA1
PGR
Description
cyclin A1
progesterone receptor
Image
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Chromatin
Nucleoplasm
Mitochondrial Outer Membrane
Cytosol
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Identical Protein Binding
ATPase Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
Ovulation From Ovarian Follicle
Epithelial Cell Maturation
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Cell-cell Signaling
Negative Regulation Of Gene Expression
Intracellular Steroid Hormone Receptor Signaling Pathway
Paracrine Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Regulation Of Epithelial Cell Proliferation
Progesterone Receptor Signaling Pathway
Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Pathways
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Nuclear signaling by ERBB4
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Estrogen-dependent gene expression
Drugs
Etonogestrel
Desogestrel
Megestrol acetate
Levonorgestrel
Dydrogesterone
Progesterone
Spironolactone
Lindane
Fluticasone propionate
Medroxyprogesterone acetate
Mitotane
Norethisterone
Mometasone
Ethynodiol diacetate
Mifepristone
Norgestimate
Drospirenone
Danazol
Oxybenzone
Allylestrenol
Phthalic Acid
Metribolone
Tanaproget
Telapristone acetate
Asoprisnil
Norelgestromin
Gestodene
Hydroxyprogesterone caproate
Ulipristal
Fluticasone furoate
Dienogest
Medrogestone
Norgestrel
Homosalate
Enzacamene
Gestrinone
Darolutamide
Demegestone
Fluticasone
Mometasone furoate
Segesterone acetate
Diseases
GWAS
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Diastolic blood pressure (
30224653
)
Length of menstrual cycle (
30202859
)
Menarche (age at onset) (
25231870
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Interacting Genes
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
53 interacting genes:
ANP32A
APEX2
ARID1A
BATF3
BCAS2
BMI1
BRCA1
CCNA1
CCNA2
CDC25B
CDK2
COPS5
CSNK2A1
CUEDC2
DAP3
DDX54
DNAJA1
ESR1
FKBP5
HMGB1
HMGB2
HSPA1A
JDP2
KAT2B
KLF9
NCOA1
NCOA3
NR0B1
PIAS1
PIAS2
PIAS3
POU2F1
POU2F2
PRKDC
PRMT2
RBM23
RBM39
RELA
RNF4
SGTA
SMARCD1
SMARCE1
SNW1
SORBS1
SRC
TAF1B
TDG
TRIM24
UBE3A
UBR5
XRCC5
XRCC6
ZBTB17
Entrez ID
8900
5241
HPRD ID
04946
07077
Ensembl ID
ENSG00000133101
ENSG00000082175
Uniprot IDs
A0A140VJG0
P78396
P06401
PDB IDs
1A28
1E3K
1SQN
1SR7
1ZUC
2C7A
2OVH
2OVM
2W8Y
3D90
3G8O
3HQ5
3KBA
3ZR7
3ZRA
3ZRB
4A2J
4APU
4OAR
5CC0
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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