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CCNA1 and E2F1
Data Source:
HPRD
(in vivo, in vitro)
CCNA1
E2F1
Description
cyclin A1
E2F transcription factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Viral Process
Forebrain Development
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of G0 To G1 Transition
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Interacting Genes
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
82 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM2
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
Entrez ID
8900
1869
HPRD ID
04946
01806
Ensembl ID
ENSG00000133101
ENSG00000101412
Uniprot IDs
A0A140VJG0
P78396
Q01094
Q9BSD8
PDB IDs
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
Enriched GO Terms of Interacting Partners
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