E2F1 and PURA

Data Source:
HPRD (in vitro, in vivo)

		E2F1	PURA
Description		E2F transcription factor 1	purine rich element binding protein A
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Centrosome Protein-containing Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex	Chromosome, Telomeric Region Nucleus Dendrite Cytoplasm Neuronal Cell Body Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding Transcription Factor Binding Purine-rich Negative Regulatory Element Binding SMAD Binding
	Biological Process	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Viral Process Forebrain Development Positive Regulation Of Apoptotic Process Anoikis Negative Regulation Of DNA Binding Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Positive Regulation Of Glial Cell Proliferation Negative Regulation Of G0 To G1 Transition Negative Regulation Of Fat Cell Proliferation Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II DNA Unwinding Involved In DNA Replication DNA Replication Initiation Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Cell Differentiation Lymphocyte Proliferation Epithelial Cell Proliferation Dendritic Transport Of Messenger Ribonucleoprotein Complex
Pathways		Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDC6 association with the ORC:origin complex G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Height ( 31562340)	Body mass index ( 26426971)
Interacting Genes		82 interacting genes: ARID3A ATAD2 ATM ATR BIN1 BIRC2 BRCA1 BRD2 BRMS1 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 CUL2 DDB2 DIABLO E2F6 EP300 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MTA1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NFKB1 NPDC1 NRIP1 NSMCE3 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RBL1 RNF126 RNF144A SERTAD2 SETD7 SIRT1 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP UBE3A UCHL5 VHL YWHAQ	57 interacting genes: ADAP1 CCNT1 CDK5 E2F1 IL7R MIR1-1 MIR106B MIR122 MIR128-1 MIR128-2 MIR140 MIR143 MIR155 MIR15B MIR16-2 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20B MIR21 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR7-1 MIR7-2 MIR9-2 MIR92A2 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PTEN PURB RAF1 RB1 SP1 YBX1
Entrez ID		1869	5813
HPRD ID		01806	02721
Ensembl ID		ENSG00000101412	ENSG00000185129
Uniprot IDs		Q01094 Q9BSD8	Q00577
PDB IDs		1H24 1O9K 2AZE 5M9N 5M9O 6G0P 6ULS
Enriched GO Terms of Interacting Partners?
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