EIF2B2 and EIF2B5

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EIF2B2	EIF2B5
Description		eukaryotic translation initiation factor 2B subunit beta	eukaryotic translation initiation factor 2B subunit epsilon
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Ovarian Follicle Development Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Ovarian Follicle Development Translational Initiation Response To Heat Response To Glucose Astrocyte Development Oligodendrocyte Development Response To Endoplasmic Reticulum Stress Myelination Response To Peptide Hormone Positive Regulation Of Translational Initiation Astrocyte Differentiation Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway
Pathways		Recycling of eIF2:GDP	Recycling of eIF2:GDP
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Coronary artery disease ( 33020668) Mood instability ( 29187730) Youthful appearance (self-reported) ( 32339537)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494 27863252) Major depressive disorder ( 22472876) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 PCGF6 TET2	12 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B STX11
Entrez ID		8892	8893
HPRD ID		05923	04898
Ensembl ID		ENSG00000119718	ENSG00000145191
Uniprot IDs		P49770 Q53XC2	Q13144
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z	3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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