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EIF2B2 and EIF2S1
Data Source:
HPRD
(in vivo)
EIF2B2
EIF2S1
Description
eukaryotic translation initiation factor 2B subunit beta
eukaryotic translation initiation factor 2 subunit alpha
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 2B Complex
Nucleus
Cytosol
Polysome
Eukaryotic Translation Initiation Factor 2 Complex
Eukaryotic Translation Initiation Factor 2B Complex
Cytoplasmic Stress Granule
Membrane
Eukaryotic 48S Preinitiation Complex
Multi-eIF Complex
Translation Initiation Ternary Complex
Synapse
Extracellular Exosome
Glial Limiting End-foot
Molecular Function
Translation Initiation Factor Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
ATP Binding
GTP Binding
RNA Binding
Translation Initiation Factor Activity
Protein Binding
Ribosome Binding
Biological Process
Ovarian Follicle Development
Translational Initiation
Regulation Of Translational Initiation
Central Nervous System Development
Response To Heat
Response To Glucose
Oligodendrocyte Development
Myelination
Response To Peptide Hormone
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Translational Initiation
Aging
Negative Regulation Of Translational Initiation In Response To Stress
Stress Granule Assembly
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To UV
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Protein Autophosphorylation
Transmembrane Transport
Positive Regulation Of Neuron Death
Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Response To Manganese-induced Endoplasmic Reticulum Stress
Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways
Recycling of eIF2:GDP
L13a-mediated translational silencing of Ceruloplasmin expression
PERK regulates gene expression
PERK regulates gene expression
ABC-family proteins mediated transport
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Recycling of eIF2:GDP
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS
Coronary artery disease (
33020668
)
Mood instability (
29187730
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
12 interacting genes:
APP
C9orf72
CCT3
CSNK2A2
EIF2B1
EIF2B4
EIF2B5
EIF2S1
MRFAP1L1
NCK1
PCGF6
TET2
26 interacting genes:
ACTN1
CASP3
CASP6
CDC37
CSNK2A1
EIF1AX
EIF2AK1
EIF2AK2
EIF2AK3
EIF2B1
EIF2B2
EIF2B3
EIF2B4
EIF2S2
HSP90AA1
HSPB1
MELK
P4HB
PPP1R15A
PRKCA
PRKCD
PRMT7
SFN
TERT
THAP12
VAC14
Entrez ID
8892
1965
HPRD ID
05923
04881
Ensembl ID
ENSG00000119718
ENSG00000134001
Uniprot IDs
P49770
Q53XC2
P05198
Q53XC0
PDB IDs
6CAJ
6EZO
6K71
6K72
6O81
6O85
6O9Z
1KL9
1Q8K
6K71
6K72
6O81
6O85
6O9Z
6YBV
6ZMW
6ZP4
7A09
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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