Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
EIF2B2 and NCK1
Data Source:
HPRD
(in vivo, in vitro)
EIF2B2
NCK1
Description
eukaryotic translation initiation factor 2B subunit beta
NCK adaptor protein 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 2B Complex
Protein Phosphatase Type 1 Complex
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Ribosome
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Molecular Function
Translation Initiation Factor Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
ATP Binding
GTP Binding
Protein Kinase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Cytoskeletal Anchor Activity
Protein Domain Specific Binding
Signaling Receptor Complex Adaptor Activity
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Signaling Adaptor Activity
Cadherin Binding
Ephrin Receptor Binding
Eukaryotic Initiation Factor EIF2 Binding
Biological Process
Ovarian Follicle Development
Translational Initiation
Regulation Of Translational Initiation
Central Nervous System Development
Response To Heat
Response To Glucose
Oligodendrocyte Development
Myelination
Response To Peptide Hormone
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Negative Regulation Of Protein Kinase Activity
Substrate-dependent Cell Migration, Cell Extension
Actin Filament Organization
Signal Complex Assembly
Positive Regulation Of Neuron Projection Development
Lamellipodium Assembly
Regulation Of Cell Migration
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Response To Other Organism
Negative Regulation Of Cell Death
Peptidyl-serine Dephosphorylation
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cap-dependent Translational Initiation
Positive Regulation Of Cap-independent Translational Initiation
Negative Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
Recycling of eIF2:GDP
Downstream signal transduction
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
Nephrin family interactions
DCC mediated attractive signaling
DCC mediated attractive signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS
Coronary artery disease (
33020668
)
Mood instability (
29187730
)
Youthful appearance (self-reported) (
32339537
)
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Blood urea nitrogen levels (
31152163
)
Body mass index (
25673413
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
12 interacting genes:
APP
C9orf72
CCT3
CSNK2A2
EIF2B1
EIF2B4
EIF2B5
EIF2S1
MRFAP1L1
NCK1
PCGF6
TET2
95 interacting genes:
ABI1
ABI2
ABL1
ADAM15
ADGRL2
ARHGAP32
ARHGEF7
BCAR1
BLNK
BRK1
CAV2
CBL
CBLB
CD3E
CHN2
CRK
CSNK1G2
CYFIP2
DAG1
DCC
DLGAP4
DNM1
DOK1
DOK2
DRD3
DRD4
EFS
EGFR
EIF2B2
EIF2S2
EPHB1
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FCHO1
FGFR1
FLT1
FLT3
FRS2
GAB1
GAB2
GMPPA
HOMEZ
KDR
KHDRBS1
KIAA1522
KIT
LCP2
MAP4K1
MAP4K4
MET
MINK1
NCKAP1
NCKAP5
NCKIPSD
NEDD9
NHSL2
NPHS1
NTRK2
NUTM2F
OLIG1
PAK1
PAK2
PAK3
PDGFRB
PFN1
PHC2
PIK3AP1
PIK3R3
PKN2
PLCG1
PTK2
PXN
RAC1
RASA1
RHOU
RRAS
SH2D1A
SHANK3
SOCS1
SOCS7
SORBS3
SOS1
SYNJ2
SYNPO
TBK1
TNIK
TNK2
UBA52
WAS
WASF1
WASL
WIPF1
Entrez ID
8892
4690
HPRD ID
05923
02740
Ensembl ID
ENSG00000119718
ENSG00000158092
Uniprot IDs
P49770
Q53XC2
A0A0S2Z4Y3
P16333
PDB IDs
6CAJ
6EZO
6K71
6K72
6O81
6O85
6O9Z
2CI8
2CI9
2CUB
2JS0
2JS2
2JW4
5QU1
5QU2
5QU3
5QU4
5QU5
5QU6
5QU7
5QU8
5QUA
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?