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EIF2B2 and CSNK2A2
Data Source:
BioGRID
(two hybrid)
EIF2B2
CSNK2A2
Description
eukaryotic translation initiation factor 2B subunit beta
casein kinase 2 alpha 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Eukaryotic Translation Initiation Factor 2B Complex
Chromatin
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Protein Kinase CK2 Complex
PcG Protein Complex
Molecular Function
Translation Initiation Factor Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
ATP Binding
GTP Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein N-terminus Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Ovarian Follicle Development
Translational Initiation
Regulation Of Translational Initiation
Central Nervous System Development
Response To Heat
Response To Glucose
Oligodendrocyte Development
Myelination
Response To Peptide Hormone
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Protein Folding
Phosphatidylcholine Biosynthetic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Wnt Signaling Pathway
Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebral Cortex Development
Regulation Of Cell Cycle
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Regulation Of Chromosome Separation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Recycling of eIF2:GDP
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
Drugs
[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
Fostamatinib
Diseases
Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS
Coronary artery disease (
33020668
)
Mood instability (
29187730
)
Youthful appearance (self-reported) (
32339537
)
Primary biliary cholangitis (
28425483
)
Rosacea symptom severity (
29771307
)
Systemic lupus erythematosus (
28714469
)
Telomere length (
24795349
)
Interacting Genes
12 interacting genes:
APP
C9orf72
CCT3
CSNK2A2
EIF2B1
EIF2B4
EIF2B5
EIF2S1
MRFAP1L1
NCK1
PCGF6
TET2
102 interacting genes:
ABCA1
ACACA
ADH1A
AQP4
ARRB2
ASL
ATF1
ATF2
ATG16L1
BHLHE41
BID
CABP1
CALM1
CASQ2
CAV1
CDC37
CLTB
CREBBP
CREM
CSN3
CSNK2B
CTDP1
DCPS
DELEC1
EEF1B2
EIF2B2
EIF2B5
EIF4EBP1
ERCC6
ERH
FGF1
FGF2
FKBP3
FOS
GTF2A1
GTF2A1L
H1-2
HDAC1
HDAC2
HDAC6
HMGA1
HMGA2
HNRNPC
HSP90AA1
HSP90B1
HSPH1
IL16
KDM1A
KIF1C
KLF1
LAMC3
LGALS3
MAF1
MAPK14
MDM2
MGMT
MS4A1
MYC
MYCN
MYF5
NAP1L4
NCL
NR1D2
P4HB
PAK1
PICK1
PIN1
PIN4
PPP1R1B
PPP1R2
PPP1R8
PRNP
PTEN
PTPN1
PTPRC
RAD1
RAD9A
RELA
RGS19
SAT1
SLC18A2
SMURF1
SNCA
SNX6
SPIB
SPP1
STX1A
TCF7L2
TCOF1
TGFBR1
TGM2
TOP1
TP53
TP63
TRIM41
TTLL12
UBE2R2
WAS
XRCC1
ZNF219
ZNF670
ZNHIT3
Entrez ID
8892
1459
HPRD ID
05923
00279
Ensembl ID
ENSG00000119718
ENSG00000070770
Uniprot IDs
P49770
Q53XC2
P19784
PDB IDs
6CAJ
6EZO
6K71
6K72
6O81
6O85
6O9Z
3E3B
3OFM
3U87
5M4U
5M56
5OOI
5Y9M
5YF9
5YWM
6HMB
6HMC
6HMD
6HMQ
6L20
6QY8
6QY9
6TE2
6TEW
6TGU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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