EIF2B2 and NPC2

Data Source:
BioGRID (affinity chromatography technology)

		EIF2B2	NPC2
Description		eukaryotic translation initiation factor 2B subunit beta	NPC intracellular cholesterol transporter 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Ovarian Follicle Development Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer
Pathways		Recycling of eIF2:GDP	Neutrophil degranulation LDL clearance
Drugs
Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)	Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Coronary artery disease ( 33020668) Mood instability ( 29187730) Youthful appearance (self-reported) ( 32339537)	Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 PCGF6 TET2	9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4
Entrez ID		8892	10577
HPRD ID		05923	03008
Ensembl ID		ENSG00000119718	ENSG00000119655
Uniprot IDs		P49770 Q53XC2	A0A024R6C0 P61916
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z	5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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