EED and DUSP23

Data Source:
BioGRID (two hybrid)

		EED	DUSP23
Description		embryonic ectoderm development	dual specificity phosphatase 23
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol ESC/E(Z) Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Protein Binding Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Viral Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation	Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs			4-Nitrophenyl Phosphate
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZBED8 ZFP42	32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746
Entrez ID		8726	54935
HPRD ID		09343	07908
Ensembl ID		ENSG00000074266	ENSG00000158716
Uniprot IDs		E9PJK2 O75530	A0A140VJI5 Q9BVJ7
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC 6U4Y 6W7F 6W7G	2IMG 4ERC
Enriched GO Terms of Interacting Partners?
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