DUSP23 and SMPD1

Data Source:
BioGRID (two hybrid)

		DUSP23	SMPD1
Description		dual specificity phosphatase 23	sphingomyelin phosphodiesterase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Extracellular Space Lysosome Endosome Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Plasma Membrane Repair Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Positive Regulation Of Protein Dephosphorylation Wound Healing Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endocytosis Ceramide Biosynthetic Process Viral Entry Into Host Cell Response To Interleukin-1 Cellular Response To Calcium Ion
Pathways			Glycosphingolipid metabolism
Drugs		4-Nitrophenyl Phosphate	Amlodipine Chlorpromazine Desipramine Medical Cannabis
Diseases			Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)	Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Malaria ( 31844061) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746	6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		54935	6609
HPRD ID		07908	06353
Ensembl ID		ENSG00000158716	ENSG00000166311
Uniprot IDs		A0A140VJI5 Q9BVJ7	E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		2IMG 4ERC	5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?
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