EED and CDK2AP2

Data Source:
BioGRID (two hybrid)

		EED	CDK2AP2
Description		embryonic ectoderm development	cyclin dependent kinase 2 associated protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol ESC/E(Z) Complex	Nucleus Cytoplasm Microtubule
	Molecular Function	RNA Polymerase II Transcription Corepressor Binding Protein Binding Nucleosome Binding Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H3-K27 Specific)	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Viral Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation	Regulation Of Microtubule Cytoskeleton Organization Regulation Of Stem Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		42 interacting genes: AEBP2 ANXA5 AR BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 H1-1 H3C1 HDAC1 HDAC2 HDAC3 ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PJA1 PPP1CA PPP1R8 PRDM14 RACK1 RPS10 SELENBP1 SMYD3 SRPK2 TGS1 TRIM55 TRIM63 TSC22D1 UBE2W YY1 ZBED8 ZFP42	17 interacting genes: A2M APP CDK2AP1 DBN1 EED EEF1G HSF4 IKZF1 MBTPS1 MRFAP1L1 PYCR1 RCC1 RPLP1 TRA2A WARS1 YIF1A ZBTB48
Entrez ID		8726	10263
HPRD ID		09343	13242
Ensembl ID		ENSG00000074266	ENSG00000167797
Uniprot IDs		E9PJK2 O75530	O75956 Q6IAV4
PDB IDs		3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27 4W2R 4X3E 5GSA 5H13 5H14 5H15 5H17 5H19 5H24 5H25 5HYN 5IJ7 5IJ8 5K0M 5LS6 5TTW 5U5H 5U5K 5U5T 5U62 5U69 5U6D 5U8A 5U8F 5WG6 5WP3 5WUK 6B3W 6C23 6C24 6SFB 6SFC 6U4Y 6W7F 6W7G	2M1L
Enriched GO Terms of Interacting Partners?
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