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HSH2D and GAB1
Data Source:
BioGRID
(pull down)
HSH2D
GAB1
Description
hematopoietic SH2 domain containing
GRB2 associated binding protein 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Cell-cell Junction
Molecular Function
Protein Binding
Protein Binding
Biological Process
Signal Transduction
Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Insulin Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Actin Cytoskeleton Reorganization
Response To Hepatocyte Growth Factor
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
ERBB2 Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase B Signaling
Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor
Pathways
PI3K Cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PIP3 activates AKT signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
MET activates PTPN11
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Asthma (
21804548
)
Diastolic blood pressure (
27841878
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Height (
31562340
)
Malaria (
31844061
)
Systolic blood pressure (
27841878
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
21 interacting genes:
AR
CNMD
CRK
EGFR
ERBB2
ERBB3
ERBB4
FES
GAB1
KIT
LDHAL6B
MET
MPP3
OLIG1
PIK3R3
PINK1
PLPP6
RBP7
TNK2
TSC1
TSG101
73 interacting genes:
ARHGAP32
BCAR3
BLK
BLNK
BTK
C1QBP
CRK
CRKL
EGFR
EPOR
ERBB2
FCGR2B
FES
FRS2
GAB2
GRAP2
GRB2
GTF2A1L
HCK
HSH2D
INPP5D
INPPL1
INSR
ITK
JAK1
LAT2
LCK
LYN
MAP3K3
MAPK1
MAPK3
MAPK4
MARK2
MET
MST1R
NCK1
NCK2
PDGFRB
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PTK6
PTPN11
PTPN18
RASA1
RET
SH2D1B
SH2D2A
SH2D3A
SHC1
SHC3
SLA
SLA2
SOCS3
SOCS6
SOS1
SRC
STAP1
SUPT6H
SYK
SYP
TEC
TNS1
TNS3
TNS4
TRIM15
VAV1
VAV2
VAV3
YES1
Entrez ID
84941
2549
HPRD ID
12219
05116
Ensembl ID
ENSG00000196684
ENSG00000109458
Uniprot IDs
Q96JZ2
Q13480
Q9HA84
PDB IDs
2CS0
4QSY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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