HAVCR2 and SEC22A

Data Source:
BioGRID (two hybrid)

		HAVCR2	SEC22A
Description		hepatitis A virus cellular receptor 2	SEC22 homolog A, vesicle trafficking protein
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Early Endosome Cell Surface Integral Component Of Membrane Cell Junction	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Metal Ion Binding	Transporter Activity Protein Binding
	Biological Process	Adaptive Immune Response Macrophage Activation Involved In Immune Response Natural Killer Cell Tolerance Induction Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Negative Regulation Of Gene Expression Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Gram-positive Bacterium Maternal Process Involved In Female Pregnancy Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport
Pathways		Interleukin-2 family signaling	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Hypertriglyceridemia ( 23505323) Iris heterochromicity ( 30895295)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		3 interacting genes: APP SEC22A TMEM86A	106 interacting genes: ADGRG3 AQP6 ASGR2 ATP6AP2 BIK BNIP3 C10orf67 C16orf54 C16orf92 CALN1 CD207 CD300A CD7 CD74 CISD2 CLEC10A CLEC12B CLEC2D CLEC7A CREB3L1 CYB561 CYBRD1 DDIT4L DIABLO DTX2 EDA ELOVL4 ERLIN1 ERVFRD-1 FAM174A FAM209A FATE1 FUT3 GAD2 GGT6 GJB5 GJB6 GPR37L1 GRAMD2B HAVCR2 HCST HSD17B11 ICAM3 KCNJ2 LDLRAD1 LHFPL5 LMNA LPAR6 LRRC25 LSMEM2 MCOLN1 MFF MGST2 MINAR1 MS4A14 MS4A3 MS4A4A MSR1 OPRM1 PACC1 PEX12 PHB PTGES RASGRP4 RETREG3 RILPL1 RNASEK RNF144A RNF19B RNF5 SAR1A SCN3B SDHAF2 SFTPC SLC14A2 SLC30A2 SLC35C2 SLC39A2 SMIM3 SPAG4 STMN4 STOML3 STX1A STX2 STX4 SUSD3 SYNE4 TFR2 TLCD4 TMED9 TMEM106C TMEM159 TMEM174 TMEM237 TMEM45B TMEM52B TMEM71 TMEM79 TMIE TMPRSS2 TNFSF14 TP53INP1 TRAT1 TRIM59 TYRP1 ZFYVE27
Entrez ID		84868	26984
HPRD ID		16227	15313
Ensembl ID		ENSG00000135077	ENSG00000121542
Uniprot IDs		Q8TDQ0	Q96IW7
PDB IDs		5DZL 5F71 6DHB 6TXZ
Enriched GO Terms of Interacting Partners?
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