CASP7 and MEF2D

Data Source:
HPRD (in vivo, in vitro)

		CASP7	MEF2D
Description		caspase 7	myocyte enhancer factor 2D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Activating Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Adult Heart Development Muscle Organ Development Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins	Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis NGF-stimulated transcription NGF-stimulated transcription
Drugs		Fica Emricasan Incadronic acid
Diseases
GWAS		Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) TPE interval (resting) ( 32386560) White blood cell count ( 32888494)
Interacting Genes		62 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP	24 interacting genes: - APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 DNMT3L EP300 FBXO7 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SKP2 SNCA SP1 YWHAQ
Entrez ID		840	4209
HPRD ID		03457	02810
Ensembl ID		ENSG00000165806	ENSG00000116604
Uniprot IDs		A0A0A0MRL7 B4DWA2 P55210	Q14814
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z
Enriched GO Terms of Interacting Partners?
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