CASP7 and STK24

Data Source:
HPRD (in vivo, in vitro)

		CASP7	STK24
Description		caspase 7	serine/threonine kinase 24
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Proteolysis Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Protein Phosphorylation Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Starvation Negative Regulation Of Cell Migration Response To Hydrogen Peroxide Protein Autophosphorylation Regulation Of Axon Regeneration Execution Phase Of Apoptosis
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins	Apoptotic cleavage of cellular proteins Apoptotic execution phase
Drugs		Fica Emricasan Incadronic acid	Fostamatinib
Diseases
GWAS		Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)	Adult body size ( 32376654) Adventurousness ( 30643258) Alzheimer's disease ( 22159054) Educational attainment ( 25201988 23722424) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Longevity ( 20834067) Methadone dose in opioid dependence ( 28115739) Mood instability ( 31168069) Reading disability or specific language impairment (pleiotropy) ( 25065397) Triglyceride levels ( 32203549) Urinary sodium excretion ( 31409800)
Interacting Genes		62 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP	11 interacting genes: CAB39 CASP3 CASP7 CASP8 ERBB2 LRRK2 NEDD4 PDCD10 STK11 STK38L VAV2
Entrez ID		840	8428
HPRD ID		03457	10385
Ensembl ID		ENSG00000165806	ENSG00000102572
Uniprot IDs		A0A0A0MRL7 B4DWA2 P55210	B4DR80 Q5U0E6 Q6P0Y1 Q9Y6E0
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z	3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP 4O27 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ 4QNA 4QO9 4U8Z 4W8D 4W8E
Enriched GO Terms of Interacting Partners?
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