MEF2D and MAPK7

Data Source:
HPRD (in vitro, in vivo)

		MEF2D	MAPK7
Description		myocyte enhancer factor 2D	mitogen-activated protein kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Activating Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Adult Heart Development Muscle Organ Development Cell Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	MAPK Cascade Cell Cycle Signal Transduction Axon Guidance Peptidyl-serine Phosphorylation CAMP-mediated Signaling Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis NGF-stimulated transcription NGF-stimulated transcription	ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs			Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) TPE interval (resting) ( 32386560) White blood cell count ( 32888494)	Alzheimer's disease ( 30636644)
Interacting Genes		24 interacting genes: - APP ASCL1 CABIN1 CARM1 CASP7 CDK6 COPS5 DNMT3L EP300 FBXO7 HDAC4 HDAC5 MAPK14 MAPK7 MEF2A MEF2C NFATC2 PRKACA PRMT5 SKP2 SNCA SP1 YWHAQ	30 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1
Entrez ID		4209	5598
HPRD ID		02810	03952
Ensembl ID		ENSG00000116604	ENSG00000166484
Uniprot IDs		Q14814	A0A024QZ20 Q13164
PDB IDs			2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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