CASP7 and MAPT

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro, in vivo)

		CASP7	MAPT
Description		caspase 7	microtubule associated protein tau
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Speck Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Proteolysis Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Microtubule Cytoskeleton Organization Microglial Cell Activation Internal Protein Amino Acid Acetylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Signaling Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Negative Regulation Of Kinase Activity Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Neuron Death Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Diacylglycerol Kinase Activity Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Response To DNA Damage Stimulus
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins	Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Fica Emricasan Incadronic acid	Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome
GWAS		Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) HDL cholesterol levels ( 32203549) Head circumference (infant) ( 22504419) Headache ( 29397368) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 31710517 24429156) Immature fraction of reticulocytes ( 32888494) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Neutrophil percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Osteoarthrosis (time to event) ( 32589924) Parkinson's disease ( 20711177 21292315 19915575 25064009 31660654 24842889 28892059 22438815 20070850 21044948 24511991 21738487) Plasma t-tau levels ( 28100725) Pork consumption ( 32066663) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 30089514 21685912 31059154) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Red blood cell count ( 32888494) Refractive error ( 32231278) Retinal detachment or retinal break ( 31816047) Subcortical brain region volumes ( 25607358) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		62 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP	130 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CHEK1 CHEK2 CREBBP CSNK1A1 CSNK1D CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FKBP5 FYN GRB2 GSK3A GSK3B HDAC6 HOOK3 HSP90AA1 HSPA8 HSPB1 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK2 MARK3 MARK4 MASP1 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTK2B PTPA PTPN11 PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SIRT1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 UBE2D3 UBE2W USP9Y YWHAB YWHAZ
Entrez ID		840	4137
HPRD ID		03457	01142
Ensembl ID		ENSG00000165806	ENSG00000186868
Uniprot IDs		A0A0A0MRL7 B4DWA2 P55210	A0A024R9Y0 A0A024R9Y1 A0A024RA17 A0A024RA19 B3KTM0 P10636
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z	1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6LRA 6N4P 6NK4 6NWP 6NWQ 6ODG 6PXR 6QJH 6QJM 6QJP 6QJQ 6TJO 6TJX 6VH7 6VHA 6VHL 6VI3 6XLI
Enriched GO Terms of Interacting Partners?
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