AXIN2 and TXLNB

Data Source:
BioGRID (two hybrid)

		AXIN2	TXLNB
Description		axin 2	taxilin beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex	Cytoplasm
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding	Protein Binding Syntaxin Binding
	Biological Process	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases		Tooth agenesis; Hypodontia Oligodontia-colorectal cancer syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Refractive error ( 32231278)	Albumin-globulin ratio ( 29403010) Caudate volume in trauma-exposed individuals ( 29187748) Heel bone mineral density ( 30598549) Non-albumin protein levels ( 29403010) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		52 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SMAD1 SMAD3 SMAD7 STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	70 interacting genes: AXIN2 BTF3 BTF3L4 C18orf54 CAGE1 CBY2 CCDC13 CCDC14 CCDC152 CCDC196 CCDC88B CCHCR1 CDR2 CEP19 CEP57 CEP57L1 CEP63 CEP70 CFAP53 CT55 DCTN2 DEUP1 DMAP1 DYDC1 EXOC5 FAM161A FAM167A GAS8 GOLGA2 HAUS3 KIAA1328 KRT13 KRT15 KRT16 KRT26 KRT27 KRT34 KRT35 KRT37 KRT38 KRT39 KRT6A KRT75 LPXN LURAP1 LZTS1 MBIP MED4 MEOX2 MNS1 NEFL NF2 NMI ODAD3 SIKE1 SNAPC5 SOX13 STMN3 STX1A STX4 TADA3 TCL1A TXLNA UBE2I USHBP1 UTP14A VIM VPS52 WASHC3 ZNF20
Entrez ID		8313	167838
HPRD ID		04935	10793
Ensembl ID		ENSG00000168646	ENSG00000164440
Uniprot IDs		E7ES00 Q9Y2T1	H0UI60 Q8N3L3
PDB IDs
Enriched GO Terms of Interacting Partners?
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