AXIN2 and ZNF648

Data Source:
BioGRID (two hybrid)

		AXIN2	ZNF648
Description		axin 2	zinc finger protein 648
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex	Nucleus
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs
Diseases		Tooth agenesis; Hypodontia Oligodontia-colorectal cancer syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Refractive error ( 32231278)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cardiovascular heart disease in diabetics ( 23982368) HDL cholesterol ( 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Morning person ( 30696823) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		52 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SMAD1 SMAD3 SMAD7 STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	61 interacting genes: AXIN2 BEGAIN BICD2 CALCOCO2 CARD14 CCDC120 CCDC136 CCDC57 CDR2L CEP70 CYSRT1 DVL3 EVI5L FSD2 GOLGA2 GOLGA6L9 HAP1 HOOK2 HSF2BP KANK2 KRTAP1-1 KRTAP10-8 KRTAP12-3 LDOC1 LZTS2 MCC MDFI MEOX2 MID2 MTUS2 NBPF19 NOTCH2NLA NUDT22 OSBPL3 PLEKHG4 RBAK RINT1 RUBCN SSX2IP SYNE4 TEX19 TNS2 TRAF1 TRAF2 TRIM41 ZBTB8A ZCCHC13 ZNF250 ZNF260 ZNF275 ZNF317 ZNF343 ZNF438 ZNF552 ZNF620 ZNF655 ZNF71 ZNF768 ZNF792 ZNF837 ZRANB1
Entrez ID		8313	127665
HPRD ID		04935	18361
Ensembl ID		ENSG00000168646	ENSG00000179930
Uniprot IDs		E7ES00 Q9Y2T1	Q5T619
PDB IDs
Enriched GO Terms of Interacting Partners?
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