AXIN2 and ZNF124

Data Source:
BioGRID (two hybrid)

		AXIN2	ZNF124
Description		axin 2	zinc finger protein 124
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex	Nucleus
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases	Generic Transcription Pathway
Drugs
Diseases		Tooth agenesis; Hypodontia Oligodontia-colorectal cancer syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Refractive error ( 32231278)	Alcohol dependence ( 21314694)
Interacting Genes		52 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SMAD1 SMAD3 SMAD7 STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	53 interacting genes: AMMECR1 AXIN2 BACH2 BLZF1 CCDC136 CCNDBP1 CYSRT1 DISC1 FHL5 FRS3 FSD2 GLRX3 GOLGA2 GOLGA6L9 HAP1 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-2 KRTAP5-9 LDOC1 LZTS2 MDFI MEOX2 MID2 MTUS2 NBPF19 NOTCH2NLA OGT PAX6 PDE4DIP SRRM4 SSX2IP SYCE1 TCF4 TRAF1 TRIM55 TRIM63 TSGA10 UBL5 ZMAT1 ZNF526 ZNF660 ZNF837 ZRANB1
Entrez ID		8313	7678
HPRD ID		04935	01936
Ensembl ID		ENSG00000168646	ENSG00000196418
Uniprot IDs		E7ES00 Q9Y2T1	J3QKQ6 Q15973
PDB IDs
Enriched GO Terms of Interacting Partners?
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